Progress in Chemical and Biochemical Research

Review Article

A Comprehensive Review of Solvent-Induced Variability in Antioxidant Profiling of Plants Extract: Justicia secunda

Bulus Bako; Adi Hosea Danladi; Godiya Gambo Bulus; John Paul Shinggu

Volume 7, Issue 1 , January 2024, Pages 1-21

https://doi.org/10.48309/pcbr.2024.417487.1292

Abstract

Variability in antioxidant profiles, particularly within plant extracts like Justicia secunda and other plant extracts, presents a significant challenge for researchers striving to ... Read More

Original Research Article

The Impact of Sodium Dodecyl Sulfate on Methane Hydrate Volume Fraction in a Batch Rocking Cell Reactor

Abolfazl Mohammadi

Volume 7, Issue 1 , January 2024, Pages 22-33

https://doi.org/10.48309/pcbr.2024.421942.1301

Abstract

Natural gas holds significant importance as a prospective energy source for meeting growing energy demands in the future. Gas hydrates offer a solution for the transportation and storage ... Read More

Original Research Article

Theoretical Study of the Anticancer Properties of Iproplatin Drug and Comparison with Cis- Diamine- dichloro Platinum (II) (CDDP)

mohammad rizehbandi; zahra Moafi; masoud shojaee

Volume 7, Issue 1 , January 2024, Pages 34-50

https://doi.org/10.48309/pcbr.2024.412451.1281

Abstract

Numerous transnational experimenters have strived to understand the medium of action or ameliorate the efficacy of inorganic collaboration composites that have been linked to parade ... Read More Numerous transnational experimenters have strived to understand the medium of action or ameliorate the efficacy of inorganic collaboration composites that have been linked to parade anticancer exertion. The essential challenges of chemotherapy demand that new strategies be developed utilizing different mechanisms of action to intrude the cellular ministry of cancer cells. In Australia, we have served from the exploration of associates who have told ultramodern platinum chemistry by contributing to our understanding of platinum oxidation and reduction, the medium of action of cisplatin, and unique design strategies for new platinum complexes. The purpose of this review is to give some backgrounds on the history and development of platinum (II) and platinum (IV) complexes. AS an anticancer drug, Iproplatin has a similar function as cis-diamine-dichloro platinum (II) (Cisplatin), but its toxicity varies and is usually lower. In this research, a comparison of anticancer drugs was performed based on cisplatin and its use in the design of newer drugs to determine the comparative index for measuring the drug potency of this category of compounds. In addition, using theoretical calculations, the process of combining iproplatin with the bases of adenine, thymine, cytosine, and guanine forming DNA and comparing it with cisplatin was investigated from the veiwpoint of thermodynamics and activation energy. The results showed that the complex between iproplatin and the organic bases of cytosine and thymine is the most stable state. This complex can be a suitable candidate for anticancer drugs based on the results obtained for each quantum chemical parameter from DFT computational studies. Substitution of either the coordinated chloride or aqua moeities was delved under mock first-order conditions as a function of attention and temperature. Experimental data were corroborated with DFT calculations. The kinetic and mechanistic study of the ligand negotiation responses of a series of transplatinum(II) complexes was performed.

Original Research Article

Heavy Metal Pollution in the Marine Environment: A Study Contribution of Three Rivers to the Pollution at the Upper of the River Niger, Nigeria

Tabugbo I Blessing; Okechukwu Josephat Ogbuagu; Uche Eunice Ekpunobi; Vincent Nwalieji Okafor; Usman Rilwan

Volume 7, Issue 1 , January 2024, Pages 51-64

https://doi.org/10.48309/pcbr.2024.421932.1300

Abstract

Water is not only essential for life, but also it is life. Safeguarding this resource from heavy metals is good for our well-being. This research investigated heavy metals content and ... Read More

Original Research Article

Assessing Physicochemical Properties of Water: A Case Study of Rivers Flowing into River Benue in Loko Town, Nasarawa State, Nigeria

Usman Rilwan

Volume 7, Issue 1 , January 2024, Pages 65-78

https://doi.org/10.48309/pcbr.2024.423274.1306

Abstract

This study focused on the analysis of nine water samples from three selected rivers across three towns in Nasarawa State, Nigeria. These rivers are Antau River, Kotto River, and Loko ... Read More

Original Research Article

Corrosion Inhibition by Piliostigma Thoningii Extract on Mild Steel in Acidic Environment: RSM and Molecular Modeling Approach

Asmau Muhammad Sanusi; Bashir Bello Roba; Bishir Usman

Volume 7, Issue 1 , January 2024, Pages 79-99

https://doi.org/10.48309/pcbr.2024.420571.1296

Abstract

The study aimed to optimize the corrosion inhibition performance of an extract from Pilliostigma thoningii stem bark on mild steel in 1M HCl environment using Response Surface Methodology ... Read More

Review Article

The Impact of Administering (S)-4-[1-(2, 3-dimethylphenyl) ethyl]-1H-imidazole (Dexmedetomidine) during Surgery on Immediate and Long-Term Pain after Simple Mastectomy: A Systematic Review

Fariborz Rousta; Ali Sharifi

Volume 7, Issue 1 , January 2024, Pages 100-113

https://doi.org/10.48309/pcbr.2024.424516.1311

Abstract

Introduction: This systematic review will evaluate the impact of administering dexmedetomidine during surgery on immediate and long-term pain outcomes after simple mastectomy. By synthesizing ... Read More Introduction: This systematic review will evaluate the impact of administering dexmedetomidine during surgery on immediate and long-term pain outcomes after simple mastectomy. By synthesizing the available evidence, the review aims to provide a comprehensive understanding of the potential benefits of (S)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole: dexmedetomidine in this specific surgical context and inform clinical practice.Material and Methods: An extensive exploration of electronic databases, specifically PubMed, Embase, and the Cochrane Library, was undertaken to pinpoint pertinent studies (during 2000-2023). The search methodology encompassed a fusion of medical subject headings (MeSH) terms and keywords pertinent to "dexmedetomidine," "mastectomy"," Simple Mastectomy" and "postoperative pain." The search was confined to studies available in the English language. Moreover, the reference lists of identified articles and conference proceedings underwent manual scrutiny to unearth any supplementary studies of relevance.Results: Regarding postoperative pain intensity, the majority of studies reported significantly lower pain scores in the (S)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole: dexmedetomidine group compared to the control group at various time points during the immediate postoperative period(p˂0.05). (S)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole: dexmedetomidine infusion was associated with reduced pain intensity(p˂0.05), both at rest and with movement(p˃0.05), indicating improved analgesia(p˂0.05).Conclusion: Administering (S)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole: dexmedetomidine during surgery for simple mastectomy may have a positive impact on immediate and long-term pain outcomes. (S)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole: dexmedetomidine infusion is associated with reduced postoperative pain intensity, decreased opioid consumption, prolonged duration of analgesia, and improved patient satisfaction.

Progress in Chemical and Biochemical Research

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Volume & Issue: Volume 7, Issue 1, January 2024, Pages 1-113

A Comprehensive Review of Solvent-Induced Variability in Antioxidant Profiling of Plants Extract: Justicia secunda

Abstract

The Impact of Sodium Dodecyl Sulfate on Methane Hydrate Volume Fraction in a Batch Rocking Cell Reactor

Abstract

Theoretical Study of the Anticancer Properties of Iproplatin Drug and Comparison with Cis- Diamine- dichloro Platinum (II) (CDDP)

Abstract

Heavy Metal Pollution in the Marine Environment: A Study Contribution of Three Rivers to the Pollution at the Upper of the River Niger, Nigeria

Abstract

Assessing Physicochemical Properties of Water: A Case Study of Rivers Flowing into River Benue in Loko Town, Nasarawa State, Nigeria

Abstract

Corrosion Inhibition by Piliostigma Thoningii Extract on Mild Steel in Acidic Environment: RSM and Molecular Modeling Approach

Abstract

The Impact of Administering (S)-4-[1-(2, 3-dimethylphenyl) ethyl]-1H-imidazole (Dexmedetomidine) during Surgery on Immediate and Long-Term Pain after Simple Mastectomy: A Systematic Review

Abstract