Document Type : Original Research Article


1 Department of Chemistry, Ilam branch, Islamic Azad University, Ilam, Iran

2 Arta Shimi Alborz Research Center, Tehran, Iran


Lack of dopamine, which is a neurotransmitter in the brain, causes diseases such as Parkinson. Therefore, in order to diagnose and prevent these diseases, it is important to accurately measure the amount of dopamine. Aptasensor is one of the most sensitive and selective measuring tools for this purpose. In this research, a modified electrochemical sensor (Apt-AMP/AuNPs-PRGO/GCE) by nanocomposite was designed for highly accurate and selective measurement of dopamine. The results of the experiment using FTIR, SEM, and CV methods show a very favourable modification of the electron surface. Methylene blue dye was used as an indicator in this experiment and the maximum concentration and interaction time for this dye were optimized at 50 µM and 15 minutes. The electrode designed using the DPV method was able to identify and measure dopamine with a detection limit of 120 pM and a very high sensitivity compared with other compounds with the same structure.

Graphical Abstract

‎A Simple Specific Dopamine Aptasensor Based on Partially Reduced Graphene Oxide–AuNPs composite


Main Subjects

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