Progress in Chemical and Biochemical Research

The Use of Calcium Carbide in Fruit Ripening: Health Risks and Arsenic Index as a Quantitative Marker for Calcium Carbide Residue

Akolade Ridwan Oladipupo; Moshood O. Akinleye; Herbert A. B. Coker

Volume 5, Issue 2 , May 2022, , Pages 125-132

https://doi.org/10.22034/pcbr.2022.320724.1206

Abstract

Fruits are important worldwide due to their nutritional, commercial, and nutraceutical values. Doubtless, the increased demand for fruits is instrumental in the use of various artificial ... Read More

Chemical Composition, Antioxidative and Antimicrobial Activities of Different Extracts of the Leaves of Parquetina nigrescens (Asclepiadaceae)

Oluwatoyin O. Olaleye; Akolade R. Oladipupo; Bamisaye O. Oyawaluja; Herbert A. B. Coker

Volume 4, Issue 4 , December 2021, , Pages 359-371

https://doi.org/10.22034/pcbr.2021.287025.1188

Abstract

Oxidative stress has been implicated in the pathogenesis of many diseases, while multiple drug resistance constitutes a major problem in management of infectious diseases. The aforementioned ... Read More Oxidative stress has been implicated in the pathogenesis of many diseases, while multiple drug resistance constitutes a major problem in management of infectious diseases. The aforementioned problems necessitate continuous investigations for development of novel antioxidant and antimicrobial agents. Here, phytochemical constituents, antioxidant, and antimicrobial activities of n-hexane, ethyl-acetate, 70%-ethanol and methanol extracts of Parquetina nigrescens leaves were investigated. Antioxidant activities were evaluated by total phenolic content, total flavonoid content, total antioxidant capacity, reducing power, DPPH, nitric oxide, and lipid peroxidation assays. Antibacterial (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli) and antifungal (Aspergillus niger, Aspergillus flavus, Candida albican and Penicillium spp.) activities of the extracts were examined using agar well diffusion method. Phytochemical investigations revealed presence of various phytochemicals, including alkaloids, tannins, flavonoids, cardiac glycosides, and terpenoids. Total phenolic contents were in the range 0.321±0.030–0.432±0.030 mg gallic acid/g extract, while total flavonoid contents were in the range 0.020±0.003–0.064±0.006 mg quercetin/g extract. The extracts displayed moderate total antioxidant capacity (TAC) and ferric reducing power; having TAC values in the range 0.820±0.060–0.876±0.030 mg ascorbic acid/g extract and reducing powers in the range 0.01–0.68. The extracts showed moderate to high activities against DPPH radical, nitric oxide and lipid peroxidation; having IC50 values in the range 59.3±10.8–87. 1±14.2 µg/mL, 52.7±10.6–56.9±10.1 µg/mL, and 58.9±18.6–101.3±10.2 µg/mL, respectively. Furthermore, ethyl-acetate extract showed broad spectrum antibacterial activities, while n-hexane extract demonstrated narrow spectrum antifungal activity. These findings suggest that P. nigrescens leaves have potentials as source of antioxidant and antimicrobial agents.

Effect of Phaulopsis falcisepala (Acanthaceae) Leaves and Stems on Mitotic Arrest and Induction of Chromosomal Changes in Meristematic Cells of Allium Cepa

Akolade Ridwan Oladipupo; Chinwe Stephenie Alaribe; Tolulope A. Akintemi; Herbert A. B. Coker

Volume 4, Issue 2 , April 2021, , Pages 134-147

https://doi.org/10.22034/pcbr.2021.256993.1163

Abstract

< p>Phaulopsis falcisepala is an herb found in the forest zone of West Africa. It is applied ethnomedicinally for treating wounds and cancer. This study investigated the chemical ... Read More

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Author = Akolade Ridwan Oladipupo

The Use of Calcium Carbide in Fruit Ripening: Health Risks and Arsenic Index as a Quantitative Marker for Calcium Carbide Residue

Abstract

Chemical Composition, Antioxidative and Antimicrobial Activities of Different Extracts of the Leaves of Parquetina nigrescens (Asclepiadaceae)

Abstract

Effect of Phaulopsis falcisepala (Acanthaceae) Leaves and Stems on Mitotic Arrest and Induction of Chromosomal Changes in Meristematic Cells of Allium Cepa

Abstract