Document Type: Original Research Article


1 Department of Biology, Faculty of Science, Shiraz University, Shiraz. Iran

2 General Practitioner, School of Medical sciences, Tehran Branch, Islamic Azad University, Tehran, Iran


In this study 'Therapeutic Effects of Hydro-alcoholic Extract of Papaver Rhoeas on Cardiovascular side effect of MIA Induced Osteoarthritis in male Rat is investigated. OA model in 35 male rats was created by injection of monosodium iodoacetate(MIA) into the right knee joint and then gavage with extract of Papaver Rhoeas for14 days, on day 30 The veins and arteries of the animal were then for injection and then Blood pressure parameters (systolic, diastolic, mean arterial pressure) were recorded and analysis effect of cholinergic and niterergic system .The results were analyzed by SPSS software. The effect of oral extracts of Papaver Rhoeas (200 mg/kg Dosage) on Systolic, diastolic, mean arterial pressure (mmHg) and heart rate (Beat/min) reduced compared with negative group (P <0/05). According to findings, extract of Papaver Rhoeas has a decreasing effect on blood pressure in rats with OA and have been observed at 200mg/kg doses, the least joint damage and the best physiological function of the heart. This effect may be due to inhibition of the niterergic and cholinergic system.

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