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Document Type : Original Research Article

Authors

Faculty of Pharmacy, University of Tripoli; Tripoli-Libya

10.33945/SAMI/PCBR.2019.2.612

Abstract

Generic drugs have increased in their popularity as the cost of their brand counterparts have arisen. Post-marketing testing of some drugs is used to assure quality, efficacy and safety of those drugs made available for public use. This is to give evidence of their effectiveness.
This study was undertaken to justify the use of generic substitution of metoprolol, spironolactone and verapamil brands marketed in Tripoli-Libya. This evaluation was achieved through QC tests for hardness, disintegration time and chemical content according to British Pharmacopoeial standards. The results of these tests were found to comply with pharmacopoial range indicating their efficiency to be used as a substituent for brands of higher price.

Graphical Abstract

Comparative study of pharmaceutical content of three different cardio vascular system drugs marketed in Tripoli- Libya

Keywords

Main Subjects

[1]    National Association of Chain Drug Stores.’ Industry- facts-at-a-Glance’. 2008 available at www.nacds.org/wmspage.cfm?parm1=507.
[2]    US Food and Drug Administration, Center for DrugEvaluation and Research. What are generic drugs?Available from: http://www.fda.gov/cder/ogd/index.htm#Introduction. Accessed: April 16, 2002. 
[3]    WHO Drug Information Vol. 28, No. 4, © 2014.
[4]    Remington Essentials of Pharmaceutics by Linda A. Felton, PhD University of New Mexico ©2012.
[5]    Quality assurance of pharmaceuticals Volume 2, Good manufacturing practices and inspection by World Health Organization© 2007.
[6]    Altons Pharmaceutics, The Design And Manufacture Of Medicines By Michael E,Aulton 3rd edition  © 2007.
[7]    The Theory and Practice of Industrial Pharmacy 2nd edition by Leon Lachman © 1970. 
[8]    The British Pharmacopoia 2010.