Progress in Chemical and Biochemical Research

‎Chalcone Derivatives Containing Imine Moieties as New Antibacterial Agents: Synthesis, SAR, Anti-biofilm Activity and Docking study

Ahmed Mutanabbi Abdula

Volume 6, Issue 1 , January 2023, , Pages 31-45

https://doi.org/10.22034/pcbr.2023.378340.1241

Abstract

A new series of 3-furan-2-yl-1-p-aryl-propenone derivatives containing imine moieties (1-7) were synthesized and characterized using spectral analysis. The synthesized derivatives were ... Read More

Chemical Composition, Antioxidative and Antimicrobial Activities of Different Extracts of the Leaves of Parquetina nigrescens (Asclepiadaceae)

Oluwatoyin O. Olaleye; Akolade R. Oladipupo; Bamisaye O. Oyawaluja; Herbert A. B. Coker

Volume 4, Issue 4 , December 2021, , Pages 359-371

https://doi.org/10.22034/pcbr.2021.287025.1188

Abstract

Oxidative stress has been implicated in the pathogenesis of many diseases, while multiple drug resistance constitutes a major problem in management of infectious diseases. The aforementioned ... Read More Oxidative stress has been implicated in the pathogenesis of many diseases, while multiple drug resistance constitutes a major problem in management of infectious diseases. The aforementioned problems necessitate continuous investigations for development of novel antioxidant and antimicrobial agents. Here, phytochemical constituents, antioxidant, and antimicrobial activities of n-hexane, ethyl-acetate, 70%-ethanol and methanol extracts of Parquetina nigrescens leaves were investigated. Antioxidant activities were evaluated by total phenolic content, total flavonoid content, total antioxidant capacity, reducing power, DPPH, nitric oxide, and lipid peroxidation assays. Antibacterial (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli) and antifungal (Aspergillus niger, Aspergillus flavus, Candida albican and Penicillium spp.) activities of the extracts were examined using agar well diffusion method. Phytochemical investigations revealed presence of various phytochemicals, including alkaloids, tannins, flavonoids, cardiac glycosides, and terpenoids. Total phenolic contents were in the range 0.321±0.030–0.432±0.030 mg gallic acid/g extract, while total flavonoid contents were in the range 0.020±0.003–0.064±0.006 mg quercetin/g extract. The extracts displayed moderate total antioxidant capacity (TAC) and ferric reducing power; having TAC values in the range 0.820±0.060–0.876±0.030 mg ascorbic acid/g extract and reducing powers in the range 0.01–0.68. The extracts showed moderate to high activities against DPPH radical, nitric oxide and lipid peroxidation; having IC50 values in the range 59.3±10.8–87. 1±14.2 µg/mL, 52.7±10.6–56.9±10.1 µg/mL, and 58.9±18.6–101.3±10.2 µg/mL, respectively. Furthermore, ethyl-acetate extract showed broad spectrum antibacterial activities, while n-hexane extract demonstrated narrow spectrum antifungal activity. These findings suggest that P. nigrescens leaves have potentials as source of antioxidant and antimicrobial agents.

Phytochemical Analysis, Antibacterial and antioxidant Activities of Essential Oil from Hibiscus sabdariffa (L) Seeds, (Sudanese Karkadi)

Tuhami Hagr; Ibrahim Adam

Volume 3, Issue 3 , July 2020, , Pages 194-201

https://doi.org/10.33945/SAMI/PCBR.2020.3.2

Abstract

In this study we investigated the chemical constituents, phytochemical screening of the essential oil from H. sabdariffa (L) Seeds, (Sudanese Karkadi) and evaluated its potential antibacterial ... Read More

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Keywords = Antibacterial

‎Chalcone Derivatives Containing Imine Moieties as New Antibacterial Agents: Synthesis, SAR, Anti-biofilm Activity and Docking study

Abstract

Chemical Composition, Antioxidative and Antimicrobial Activities of Different Extracts of the Leaves of Parquetina nigrescens (Asclepiadaceae)

Abstract

Phytochemical Analysis, Antibacterial and antioxidant Activities of Essential Oil from Hibiscus sabdariffa (L) Seeds, (Sudanese Karkadi)

Abstract