Progress in Chemical and Biochemical Research

Original Research Article

Effect Study of Verbena Ofﬁcinalis Medicinal Herb on Sex Hormones Level of NMRI Female Rats During Pregnancy

Yadolah Edalatpanah; marzieh avazzadeh; zainab abraheh; fariba enayatiparvar; reza bzorgyan; leila moradi jaferi; susan rostampour

Volume 6, Issue 1 , January 2023, Pages 1-10

https://doi.org/10.22034/pcbr.2022.330897.1215

Abstract

The use of medicinal herbs in the treatment of diseases has become increasingly widespread, in this regard the Verbena ofﬁcinalis is considered as one of the herbs that affects pregnancy. ... Read More The use of medicinal herbs in the treatment of diseases has become increasingly widespread, in this regard the Verbena ofﬁcinalis is considered as one of the herbs that affects pregnancy. The present study was conducted to investigate the Verbena ofﬁcinalis herb on the level of sex hormones of NMRI female rats during pregnancy. This is an experimental study which divided 40 rats into 5 groups of 8 each and the groups included control, sham, and experimental with 5, 10, and 15 mM alcoholic extract of Verbena ofﬁcinalis. The serum levels measurement of FSH and LH hormones was done using ELISA (Biotech) method. After blood sampling, the ovaries were stained with hematoxylin eosin for histological examination. Cell count and thickness measurement of different ovarian cells, primitive follicles, primary follicles, growing follicles, graph follicles, lymph nodes, blood vessels, atretic follicles, and abnormal follicles (1 or 2 oocytes in one follicle) were examined microscopically in 6 segments of tissue segments from different groups. The statistical analysis was performed using SPSS23 software.The findings of the present study showed that the consumption of alcoholic extract of Verbena ofﬁcinalis significantly reduced the levels of LH, FSH, the number of abnormal follicles, the number of graph follicles, and the number of corpus luteum in the experimental group compared to the control group (p≤0.05), the number of primary follicles, the number of growing follicles, the number of ethereal follicles, and the number of blood vessels in the experimental group compared to the control group (p≤0.05). The weight, ovarian weight, ovarian diameter, secondary follicle diameter, and primary follicle diameter decreased in experimental groups compared to control group and sham group; however, this decrease was not significant and abnormal follicle diameter in experimental groups compared to control group and group. Sham increased but this increase was not significant (p> 0.05). The results of the present study show that consumption of Verbena ofﬁcinalis medicinal plant can be effective in abortion

Original Research Article

Combined QSAR Modeling, Molecular Docking Screening, and Pharmacokinetics Analyses for the Design of Novel 2, 6-Diarylidene Cyclohexanone Analogs as Potent Anti-Leishmanial Agents

Fabian Audu Ugbe; Gideon Adamu Shallangwa; Adamu Uzairu; Ibrahim Abdulkadir

Volume 6, Issue 1 , January 2023, Pages 11-30

https://doi.org/10.22034/pcbr.2022.366493.1234

Abstract

The current research was conducted as part of the anti-leishmanial drug discovery effort towards new drug molecules with attributes that overcome the limitations of existing therapies. ... Read More

Original Research Article

‎Investigating the Problems of Sulfur in Hydrocarbon Cuts

Roozbeh Behzadi

Volume 6, Issue 1 , January 2023, Pages 31-49

https://doi.org/10.22034/pcbr.2023.377812.1239

Abstract

The removal of sulfur compounds in hydrocarbon fuels is important from an environmental point of view, because in the combustion process of fuels in engines, sulfur compounds in the ... Read More

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Volume & Issue: Volume 6, Issue 1, January 2023, Pages 1-80

Effect Study of Verbena Ofﬁcinalis Medicinal Herb on Sex Hormones Level of NMRI Female Rats During Pregnancy

Abstract

Combined QSAR Modeling, Molecular Docking Screening, and Pharmacokinetics Analyses for the Design of Novel 2, 6-Diarylidene Cyclohexanone Analogs as Potent Anti-Leishmanial Agents

Abstract

‎Investigating the Problems of Sulfur in Hydrocarbon Cuts

Abstract