Progress in Chemical and Biochemical Research

Original Research Article

Preferential Solvation of Mordant Black and Solochrome Dark Blue in Mixed Solvent Systems

Olusegun E. Thomas; Olajire. A. Adegoke; AbdulWarith. F. Kazeem; Ikechukwu. C. Ezeuchenne

Volume 2, Issue 2 , May 2019, Pages 40-52

https://doi.org/10.33945/SAMI/PCBR.2019.2.2.1

Abstract

In this study, the preferential solvation of Mordant Black and Solochrome Dark Blue were investigated in mixed solvent systems of aqueous methanol, ethanol, propan-1-ol, propan-2-ol, ... Read More

Original Research Article

Biotic / Abiotic Stress Influences on Human Epidermal Keratinocyte Cells

Seyed Mohammad Motevalli; Fateme Mirzajani

Volume 2, Issue 2 , May 2019, Pages 53-58

https://doi.org/10.33945/SAMI/PCBR.2019.2.2.2

Abstract

Human epidermal keratinocyte cells are the first defence blocks against the aggressive agents such as pathogens and xenobiotic materials. Synthesis process of the cellular proteins ... Read More

Original Research Article

Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst

Ahmad Reza Moosavi-Zare; Hamid Goudarziafshar; Zahra Jalilian

Volume 2, Issue 2 , May 2019, Pages 59-65

https://doi.org/10.33945/SAMI/PCBR.2019.2.2.3

Abstract

In this work, we have reported the preparation of pyrano[2,3-d]pyrimidine dione derivatives by the tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes ... Read More

Original Research Article

Isolation and characterization of spinasterol from crossopterxy febrifuga stem bark

Muluh Emmanuel Khan; Adebayo Samuel Adeiza; Terumon Amon Tor-Anyiin; Abel Alexander

Volume 2, Issue 2 , May 2019, Pages 66-73

https://doi.org/10.33945/SAMI/PCBR.2019.2.2.5

Abstract

In this study, stem bark of Crossopteryx febrifuga (Rubiaceae), a traditional medicinal, plant used for treatment of various diseases. The diseases was phytochemically screened by cold ... Read More

Original Research Article

Acute and subchronic toxicity profiles of Melastomastrum capitatum (Vahl) Fern. (Melastomataceae) root aqueous extract in Swiss albino mice

Cletus Anes Ukwubile; Emmanuel Oise Ikpefan; Mathias Simon Bingari; Livinus Tam

Volume 2, Issue 2 , May 2019, Pages 74-83

https://doi.org/10.33945/SAMI/pcbr.2019.2.2.6

Abstract

Melastomastrum capitatum is a plant whose leaf extract is popularly known for its ability to cure cancer of the ovary in Mambila plateau towns in Nigeria. Apart from the leaves, the ... Read More Melastomastrum capitatum is a plant whose leaf extract is popularly known for its ability to cure cancer of the ovary in Mambila plateau towns in Nigeria. Apart from the leaves, the root extract has been used to manage various diseases such as bacterial infections, pains, and diabetes. As a result of these health benefits, liver and vital organ damage are often associated with short (acute) or long (subchronic) intake of this plant decoction in traditional medicines. This present study was carried out to determine short and long (subchronic) terms effect of the root aqueous extract for the treatment of diseases especially diabetes by the Fulani tribe in Mambila plateau in Taraba State, Nigeria. Acute and subchronic toxicity studies were carried out following the guidelines stipulated by the Organization for Economic Cooperation and Development (OECD). In the acute toxicity study, a limit test dose of 2000 mg/kg body weight (b.w) of aqueous root extract was administered by oral route into five Swiss albino mice consisting of five groups of one mouse per group. Observations were carefully made for signs of toxicity for the first 4 hours and then once daily for 2 weeks. A lower dose of 300 mg/kg b.w administered to the mice do not show any sign of acute toxicity unlike the higher dose which produced signs such a reddish eyes, itching and restlessness which last only a few minutes of extract administration. Subchronic toxicity study revealed that root extract of the plant is slightly toxic as had shown by results of most of blood parameters investigated such as WBC, PCV, ALT, AST, ALP, serum electrolytes, etc. However, our results showed that root aqueous extract of M. capitatum is well tolerated at the doses investigated as there was no major damage to vital organs like the liver, kidney and heart of the animals. The study therefore showed that the root extract of the plant is safe for use as an ethnomedicinal prescription for diseases in traditional medicine.

Progress in Chemical and Biochemical Research

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Volume & Issue: Volume 2, Issue 2, May 2019, Pages 40-83

Preferential Solvation of Mordant Black and Solochrome Dark Blue in Mixed Solvent Systems

Abstract

Biotic / Abiotic Stress Influences on Human Epidermal Keratinocyte Cells

Abstract

Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst

Abstract

Isolation and characterization of spinasterol from crossopterxy febrifuga stem bark

Abstract

Acute and subchronic toxicity profiles of Melastomastrum capitatum (Vahl) Fern. (Melastomataceae) root aqueous extract in Swiss albino mice

Abstract