Document Type: Original Research Article

Authors

Sayyed Jamaleddin Asadabadi University, Asadabad, 6541861841, I. R. Iran

Abstract

In this work, we have reported the preparation of pyrano[2,3-d]pyrimidine dione derivatives by the tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives at the presence of isonicotinic acid as an efficient organocatalyst.

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[1] Moosavi-Zare A. R., Zolfigol M. A., Khaledian O., Khakyzadeh V., farahani M. D., Beyzavi M. H., Kruger H. G., Chem. Engin. J., 2014, 248: 122

[2] Moosavi-Zare A. R., Zolfigol M. A., Khaledian O., Khakyzadeh V., Farahani M. D., Kruger H. G., New J. Chem., 2014, 38: 2342

 [3] Khazaei A., Abbasi F., Moosavi-Zare A. R., New J. Chem., 2014, 38: 5287

[4] Khazaei A., Moosavi-Zare A. R., Afshar-Hezarkhani H., Khakyzadeh V., RSC Adv., 2014, 4: 32142

[5] Zolfigol M. A., Khazaei A., Moosavi-Zare A. R., Afsar J., Khakyzadeh V., Khaledian O.,
J. Chin. Chem. Soc., 2015, 62: 398

[6] Kitamura N., Onishi A., Eur. Pat., 163599, 1984, Chem. Abstr. 1984, 104: 186439

[7] Davoll J., Clarke J., Eislager E. F., J. Med. Chem., 1972, 15: 837

[8] Ahluwalia V. K., Batla R., Khurana A., Kumar R., Indian J. Chem. Sec. B, 1990, 29: 1141

[9] Kretzschmer E., Pharmazie, 1980, 35: 253

[10] Khazaei A., Alavi-Nik H. A., Moosavi-Zare, A. R., J. Chin. Chem. Soc. 2015, 62: 675

[11] Shestopalov A. A., Rodinovskaya L. A., Shestopalov A. M., Litvinov V. P., Russ Chem Bull., 2004, 53: 724

[12] Yu J., Wang, H. Synth. Commun., 2005, 35: 3133

[13] Heravi M. M., Ghods A., Derikvand F., Bakhtiari K., Bamoharram, F. F., J. Iran. Chem. Soc., 2010, 7: 615

[14] Mobinikhaledi A., Foroughifar, N., Bodaghi Fard, M. A., Synth React Inorg, Met-Org, Nano-Met Chem., 2010, 40: 179

[15] Bararjanian, M., Balalaie, S., Movassagh, B., Amani, A. M., J. Iran. Chem. Soc., 2009, 6: 436

[16] Moosavi‐Zare  A. R., Goudarziafshar  H., Jalilian Z., Appl Organometal Chem. 2019, 33, e4584