Document Type: Short Communication


Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq



This short paper deals with the coloring phenomenon that occurs in O-bromoaniline from white to very dark. It is found that the very pure compound exhibits a significant resistance towards this phenomenon as stays for a long period without discoloring. Such a result is clearly of great interest to anyone who produces, marketing, or purchases and uses O-bromoaniline on a regular basis. The results show that the conventional methods for purification of solid compound such as recrystallization are not sufficient. It has been found that the fractional distillation under vacuum for this solid material gives a pure compound possesses a resistance against discoloring phenomenon. In particular, the listed purification procedure should allow chemical companies to produce and market a better quality product of O-bromoaniline.

Graphical Abstract


Main Subjects


[1] L. Fishbein, Aromatic amines, in: E. Atlas, et al. (Eds.), Anthropogenic compounds, Springer-Verlag Berlin Heidelberg (1984) 1-40.

[2] J. Northcott, Aniline and its derivatives, in: R.E. Kirk, D.F. Othmer (Eds.), Encyclopedia of Chemical Technology, 3rd ed., Vol. 2, John Wiley & Sons, New York (1978), 309–321.

[3] R.A. Khalil, A Study of the Factors Affecting Nitrogen-15 Nuclear Magnetic Resonance Chemical Shifts, Ph.D. Thesis, University of Mosul, Iraq (1994).

[4]  R. T. Morrison, R. N. Boyd,Organic Chemistry, 3rd ed., Boston: Allyn and Bacon, Inc., (1974) 730.

[5] R.A. Khalil, A.M.A. Saeed, Colorimetric microdetermination of bromhexine drug in aqueous solution, J. Chin. Chem. Soc., 54 (2007) 1099-1105.

[6] R.A. Khalil, R.Z. Al-Khayat, Micellar catalysis in reactions of some β-lactam antibiotics with p-dimethylaminobenzaldehyde. Phys. Chem. Liquids,   46 (2008) 34-46.

[7]Fluka Chemie AG, Industriestrasse 25, CH-9470 Buchs, Switzerland.

[8] D.D. Perrin, W.L.F. Armarego, D.R. Perrin, , Purification of Laboratory Chemicals, 2nd Ed., Oxford: Pergamon Press, (1980).

[9] R.A. Khalil., A New procedure for preparing calcium -D- saccharate from commercial sugar, National J. Chem., 9 (2003) 14-20