Sami Publishing CompanyProgress in Chemical and Biochemical Research2676-70902120190201Quantum-chemical study of geometric and energy characteristics of some bases of shiff gossipol158219210.33945/SAMI/PCBR.2019.2.15ENKhaitbaev Kh. AlisherDepartment Chemistry of natural compounds, Faculty of Chemistry National University of Uzbekistan, Tashkent. Uzbekistan0000-0001-9892-8189Toshov S. KhamzaDepartment Chemistry of natural compounds, Faculty of Chemistry National University of Uzbekistan, Tashkent. UzbekistanYuldashev Sh. IkbolDepartment Chemistry of natural compounds, Faculty of Chemistry National University of Uzbekistan, Tashkent. UzbekistanJournal Article20190112The most important aspect of modern chemistry lies in the fact that along with instrumental (physical) methods, computer modelling plays an increasing role in it. The role of molecular modelling in chemistry is quite large, despite the obvious priority of experimental research in this field of natural science. The most significant ones are theoretical results that are impossible, extremely difficult or too expensive to be obtained by experimental means.Sami Publishing CompanyProgress in Chemical and Biochemical Research2676-70902120190201Comparative study of pharmaceutical content of three different cardio vascular system drugs marketed in Tripoli- Libya6128264110.33945/SAMI/PCBR.2019.2.612ENAmira Salem ZaekFaculty of Pharmacy, University of Tripoli; Tripoli-LibyaBalsam Ali BenhamedFaculty of Pharmacy, University of Tripoli; Tripoli-LibyaMabroka Ali Al ShahomyFaculty of Pharmacy, University of Tripoli; Tripoli-LibyaRuwida KamourFaculty of Pharmacy, University of Tripoli; Tripoli-LibyaAkram EshamesFaculty of Pharmacy, University of Tripoli; Tripoli-LibyaJournal Article20190114Generic drugs have increased in their popularity as the cost of their brand counterparts have arisen. Post-marketing testing of some drugs is used to assure quality, efficacy and safety of those drugs made available for public use. This is to give evidence of their effectiveness.<br /> This study was undertaken to justify the use of generic substitution of metoprolol, spironolactone and verapamil brands marketed in Tripoli-Libya. This evaluation was achieved through QC tests for hardness, disintegration time and chemical content according to British Pharmacopoeial standards. The results of these tests were found to comply with pharmacopoial range indicating their efficiency to be used as a substituent for brands of higher price.Sami Publishing CompanyProgress in Chemical and Biochemical Research2676-70902120190201Investigation of phytochemicals in methanolic leaves extracts of Abutilon pannosum and Grewia tenax by Q-TOF LC/MS13198269010.33945/SAMI/PCBR.2019.2.1319ENMital K. AadesariyaDepartment of Chemistry, KSKV Kachchh University, Bhuj, Kachchh- 370001Vijay R. RamDepartment of Chemistry, KSKV Kachchh University, Bhuj, Kachchh- 370001Pragnesh N DaveDepartment of Chemistry, KSKV Kachchh University, Bhuj, Kachchh- 370001Department of Chemistry, Sardar Patel University, Vallabh Vidynagar-388 120 (Gujarat), IndiaJournal Article20190206The current study was carried out on the extraction, isolation, and identification of phytochemical constituents existing in the Abutilon pannosum and Grewia tenax leaves extract collected from Kachchh region of Gujarat state, India. The main aim of this study was to expose important polar phytochemicals in locally available medicinal plants using LC-Q-TOF-MS analytical techniques. The main analytical tool is liquid chromatography quadrupole time of flight mass spectrometry (LC-Q-TOF-MS) which is one of the most sophisticated and sensitive instruments that gives qualitative as well as quantitative information accurately with respect to constituents present in the sample. The continuous extraction of plant leaves was commenced by Soxhlet extractor utilizing methanol as a solvent. The crude methanolic extracts were inserted in LC-Q-TOF-MS for identification and isolation of useful phytochemicals. The results of phytochemical analysis displayed that there were significant phytochemicals found in methanol extracts of A. pannosum leaves (APL) such as alkaloids, photoproteins, antibioticand in G. tenax leaves (GTL) like alkaloids, photoproteins, glycoside, terpenoids, fatty amides, steroids, fatty alcohols, saponins, flavones, flavonols, steroid etc. Hence, methanolic extract of GTL gives good medicinal activity as compared to the APL.Sami Publishing CompanyProgress in Chemical and Biochemical Research2676-70902120190201Comparative study on different horizontal subsurface substrates in flow wetlands20238500810.33945/SAMI/PCBR.2019.2.2023ENAyman El-KhateebDepartment of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Egypt0000-0003-4014-524XM. H. MahmoudDepartment of Mathematical and Physical Engineering, Faculty of Engineering, Mansoura University, EgyptM. FakihWater and Wastewater Company, Dakahlia, EgyptJournal Article20181214A greenhouse experiment has been conducted to study the effect of using different wetland substrates that have been compiled on the basis of effluent treatment efficiency. Wetland beds have been prepared with locally available plants, in particular (Phragmites Australis). The effectiveness of the treatment was evaluated on parameters such as biological oxygen demand (BOD), chemical oxygen demand (COD), total Kjeldahl nitrogen (TKN), total suspended solids (TSS) and total phosphorus (TP). The results indicate that nutrient reduction corresponds to lower flow in wetland beds. At the lower flow rate of 2.34 m<sup>3</sup>/day, the system with plastic supports showed the highest removal efficiencies of BOD, COD, TKN, TSS and TP in percentages of 74.42, 74.9 %, 63.28, 87.49 and 71.29 %, correspondingly.Sami Publishing CompanyProgress in Chemical and Biochemical Research2676-70902120190201Development of chemically modified pencil graphite electrode based on benzo-18-crown-6 and multi-walled CNTs for determination of lead in water samples24338500910.33945/SAMI/PCBR.2019.2.2433ENWalaa Haider ElobeidUniversity of Khartoum, Faculty of Science, Department of Chemistry, Khartoum, SudanAbdalla Ahmed ElbashirUniversity of Khartoum, Faculty of Science, Department of Chemistry, Khartoum, SudanJournal Article20190106An improvement to the performance of the bare pencil graphite electrode (PGE) was made by modifying it utilizing p-amino benzene sulfonic acid (p-ABSA), benzo-18-crown-6 and multi-walled carbon nanotubes (CNTs) to detect lead (II) ions in water samples using differential pulse anodic stripping voltammetric technique. The presence of p-ABSA serves as ionic conductor while the good adsorption ability and electrical conductivity of multi-walled CNTs enhanced the sensitivity through increasing the electrochemical active surface area. Furthermore, using benzo-18-crown-6 as a molecular scavenger improved the selectivity for lead (II) ions. After optimizing the experimental and chemical parameters, the proposed electrode demonstrated linearity toward the lead (II) ions in a concentration range of 15-200 µM, and 0.99852 correlation factor at 5 sec accumulation time. The detection and qualification limits were statistically calculated based on ICH guidelines as 5.72 µM and 17.32 µM, respectively. The sensor demonstrated a very good selectivity over heavy metals for instance Zn (II), Fe (III), Cr (III), Cu (II) and Mn (VI). The developed method was adequately applied for the determination of Pb (II) ions in water samples. The results obtained by the current method were compared to the acquired results utilizing ICP-OES. According to the statistical consideration, the two methods were considered identical. Sami Publishing CompanyProgress in Chemical and Biochemical Research2676-70902120190201Tertiary cyclic amides in Vilsmeier type reaction with indoles34398501010.33945/SAMI/PCBR.2019.2.3439ENMasomeh AghazadehDepartment of Chemistry, Maku Branch, Islamic Azad University, Maku, 58619-93548, IranYoung Researchers and Elite Club, Maku Branch, Islamic Azad University, Maku,58619-93548, IranJournal Article20190110The reaction of indoles with the complex formed from tertiary cyclic amides and phosphorus oxychloride, followed by basification using sodium hydroxide, was studied. In the case of five member amide rings, 3-(1-alkyl-pyrrolidine-2-ylidene)3<em>H</em>-indoles were obtained but in the case of six and seven member amide rings, ring opening was occurred and amino ketones were obtained.