TY - JOUR ID - 106475 TI - Study of Some Hyndantion Derivatives as Anticonvulsant Agents JO - Progress in Chemical and Biochemical Research JA - PCBR LA - en SN - 2676-7090 AU - Abida, . AU - Tauquir Alam, Md AU - Asif, Mohammad AD - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, PO Box 840, Saudi Arabia AD - Department of Pharmacy, Himalayan Institute of Pharmacy and Research, Dehradun, (Uttarakhand), 248007, India Y1 - 2020 PY - 2020 VL - 3 IS - 2 SP - 93 EP - 104 KW - phenytoin KW - Hydantoin KW - anticonvulsant activity DO - 10.33945/SAMI/PCBR.2020.2.2 N2 - Hydantoin derivatives are commonly used anticonvulsant drugs. It is generally effective against partial and tonic-clonic seizures but not in absent seizures. Phenytoin is the main drug of this group and other drugs ethotoin, mephenytoin also commonly used in the therapy of epilepsies. However, they have some adverse effects and long period of therapy to seizure control. To sort out these problems, various new hydantoin derivatives as well as prodrugs like fosphenytoin were prepared. Phenytoin is effective in some cases of trigeminal and related neuralgias. Phenytoin is also used in the treatment of cardiac arrhythmias. UR - https://www.pcbiochemres.com/article_106475.html L1 - https://www.pcbiochemres.com/article_106475_0db43224441fb16781102ab71821a289.pdf ER -