Progress in Chemical and Biochemical Research

The bioactivities of the neem (seeds and leaves) against Callosobruchus maculatus on a Vigna Subterranean L.

Kaana Asemave; Titus Anure

Volume 2, Issue 3 , August 2019, , Pages 92-98

https://doi.org/10.33945/SAMI/PCBR.2019.3.2

Abstract

This research reports the novel bioactivities of neem leaves powder, neem leaves concentrate, neem seeds powder and neem seeds oil against the weevil (Callosobruchus maculatus) on bambara ... Read More

Cinnamomum zeylanicum Extract as Green Corrosion Inhibitor for Carbon Steel in Hydrochloric Acid Solutions

Abdaziz Foda; Haitham Mosallam; Ayman El-Khateeb; Mohamed Fakih

Volume 2, Issue 3 , August 2019, , Pages 120-133

https://doi.org/10.33945/SAMI/PCBR.2019.2.5

Abstract

The extract of cinnamomum have been evaluated as green inhibitor for the corrosion of Carbon steel in 1M HCl solution was investigated using weight loss, potentiodynamic polarization, ... Read More

Screening of Cassia Sieberiana (Fabaceae) Leaf Extract for In-Vitro Anti Microbial and Anti-Ulcer Activities

Emmanuel Khan Muluh; Agustine Odokpe Ugbede; Terumon Amon Tor-Anyin

Volume 2, Issue 3 , August 2019, , Pages 143-149

https://doi.org/10.33945/SAMI/PCBR.2019.2.7

Abstract

Study evaluates the in-vitro anti-microbial and anti-ulcer activity of Cassia sieberiana leaf extracts on Helicobacter pylori the major etiological agent of chronic active gastritis ... Read More

Biotic / Abiotic Stress Influences on Human Epidermal Keratinocyte Cells

Seyed Mohammad Motevalli; Fateme Mirzajani

Volume 2, Issue 2 , May 2019, , Pages 53-58

https://doi.org/10.33945/SAMI/PCBR.2019.2.2.2

Abstract

Human epidermal keratinocyte cells are the first defence blocks against the aggressive agents such as pathogens and xenobiotic materials. Synthesis process of the cellular proteins ... Read More

Acute and subchronic toxicity profiles of Melastomastrum capitatum (Vahl) Fern. (Melastomataceae) root aqueous extract in Swiss albino mice

Cletus Anes Ukwubile; Emmanuel Oise Ikpefan; Mathias Simon Bingari; Livinus Tam

Volume 2, Issue 2 , May 2019, , Pages 74-83

https://doi.org/10.33945/SAMI/pcbr.2019.2.2.6

Abstract

Melastomastrum capitatum is a plant whose leaf extract is popularly known for its ability to cure cancer of the ovary in Mambila plateau towns in Nigeria. Apart from the leaves, the ... Read More Melastomastrum capitatum is a plant whose leaf extract is popularly known for its ability to cure cancer of the ovary in Mambila plateau towns in Nigeria. Apart from the leaves, the root extract has been used to manage various diseases such as bacterial infections, pains, and diabetes. As a result of these health benefits, liver and vital organ damage are often associated with short (acute) or long (subchronic) intake of this plant decoction in traditional medicines. This present study was carried out to determine short and long (subchronic) terms effect of the root aqueous extract for the treatment of diseases especially diabetes by the Fulani tribe in Mambila plateau in Taraba State, Nigeria. Acute and subchronic toxicity studies were carried out following the guidelines stipulated by the Organization for Economic Cooperation and Development (OECD). In the acute toxicity study, a limit test dose of 2000 mg/kg body weight (b.w) of aqueous root extract was administered by oral route into five Swiss albino mice consisting of five groups of one mouse per group. Observations were carefully made for signs of toxicity for the first 4 hours and then once daily for 2 weeks. A lower dose of 300 mg/kg b.w administered to the mice do not show any sign of acute toxicity unlike the higher dose which produced signs such a reddish eyes, itching and restlessness which last only a few minutes of extract administration. Subchronic toxicity study revealed that root extract of the plant is slightly toxic as had shown by results of most of blood parameters investigated such as WBC, PCV, ALT, AST, ALP, serum electrolytes, etc. However, our results showed that root aqueous extract of M. capitatum is well tolerated at the doses investigated as there was no major damage to vital organs like the liver, kidney and heart of the animals. The study therefore showed that the root extract of the plant is safe for use as an ethnomedicinal prescription for diseases in traditional medicine.

Comparative study of pharmaceutical content of three different cardio vascular system drugs marketed in Tripoli- Libya

Amira Salem Zaek; Balsam Ali Benhamed; Mabroka Ali Al shahomy; Ruwida kamour; Akram Eshames

Volume 2, Issue 1 , February 2019, , Pages 6-12

https://doi.org/10.33945/SAMI/PCBR.2019.2.612

Abstract

Generic drugs have increased in their popularity as the cost of their brand counterparts have arisen. Post-marketing testing of some drugs is used to assure quality, efficacy and safety ... Read More

Antiulcerogenic Activity of methanol extract and solvent fractions of Stem Bark of Lannea acida (A. Rich) Against Ethanol-Induced Gastric Mucosal Injury in Albino Rats

Onoshe Solomon; Wasagu Rabiu Saidu Umar; Hassan Sanusi Wara; Abubakar Sadiq Yakubu; Madusolumou Michael Azubuike; Mbahi Asugu Mary; Hitler Louis

Volume 1, Issue 1 , October 2018, , Pages 29-39

https://doi.org/10.29088/SAMI/PCBR.2018.1.2939

Abstract

Peptic ulcer disease is one of the most prevalent gastrointestinal disorders causing tremendous human suffering worldwide. The present study was designed to evaluate the antiulcerogenic ... Read More

Progress in Chemical and Biochemical Research

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Volume 7 (2024)

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Main Subjects = Biochemical and Medical science

The bioactivities of the neem (seeds and leaves) against Callosobruchus maculatus on a Vigna Subterranean L.

Abstract

Cinnamomum zeylanicum Extract as Green Corrosion Inhibitor for Carbon Steel in Hydrochloric Acid Solutions

Abstract

Screening of Cassia Sieberiana (Fabaceae) Leaf Extract for In-Vitro Anti Microbial and Anti-Ulcer Activities

Abstract

Biotic / Abiotic Stress Influences on Human Epidermal Keratinocyte Cells

Abstract

Acute and subchronic toxicity profiles of Melastomastrum capitatum (Vahl) Fern. (Melastomataceae) root aqueous extract in Swiss albino mice

Abstract

Comparative study of pharmaceutical content of three different cardio vascular system drugs marketed in Tripoli- Libya

Abstract

Antiulcerogenic Activity of methanol extract and solvent fractions of Stem Bark of Lannea acida (A. Rich) Against Ethanol-Induced Gastric Mucosal Injury in Albino Rats

Abstract